| Triamcinolone acetonide more info |
| Mode Of Action |
It diffuses across cell membranes and forms a complex with
specific cytoplasmic receptors. These complexes then enter the cell
nucleus, binds to DNA, and stimulate transcription of messenger RNA
(mRNA). Messenger RNA leads to protein synthesis of various enzymes
that are responsible for the effects of systemic corticosteroids
|
| Drug Indication |
Allergic conditions; rheumatic arthritis; nephrotic
syndrome; collagen diseases; fulminating SLE; bronchial asthma; status
asthmaticus; severe chronic bronchial asthma; chronic ulcerative
colitis; thrombocytopenia; organ transplant; shock (cardiogenic /
traumatic). |
| Precautions |
Patient monitor if used for prolonged use; use the
lowest possible dose; use with caution in patients suffering from
diabetes mellitus; CCF; hypertension; infections; thrombo-embolism;
elderly; ureamia; and chronic renal failure. |
| Contra-Indications |
Hypersensitivity to the drug; systemic fungal
infections; live virus vaccination; IM use in idiopathic
thrombocytopenic purpura; peptic ulceration; psychosis; osteoporosis;
severe psychoneurosis; TB; ocular herpes simplex; primary glaucoma. |
| Side Effects |
Hypertension; hypersensitivity reactions; muscle mass
loss; osteoporosis; thrombo-embolism; thrombophlebitis; cardiac
arrhythmias; insomnia; fatigue; hyperglyceamia; glaucoma; cushoid
states; steroid psychosis and aggravation of pre-existing psychiatric
conditions; syncopal episodes; GI disorders; impaired wound healing;
thin fragile skin; acne; hirsutism; increased appetite and weight gain;
convulsions; pancreatitis; spontaneous fractures; increased
susceptibility to infections; peptic ulcerati |
| Dosage |
By deep I.M injection, into gluteal muscle, 40mg of
acetonide for depot effect, repeated at intervals according to the
patients response; max. single dose 100mg. |
| Pregnancy Category |
Category C |
| Pregnancy Category Description |
Drugs which, owing to their pharmacological effects,
or may be suspected of causing detrimental effects on human foetus or
neonates without causing malfunctions. These effects may be
reversible |
| Drug Category |
ENDOCRINE DRUGS |
| Drug Sub-Category |
Corticosteroids and related drugs |
